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编者按随着慢乙肝临床治愈从早期的探索阶段,逐渐到快速发展阶段,再到如今的全面深入探索阶段,临床治愈的研究也逐渐丰富和深入,越来越多的肝病医生加入到临床治愈的探索研究中来,也取得了很多令人振奋的结果。

概况

最具代表性的OSST和NEW SWITCH研究,打开了慢乙肝临床治愈探索的大门,核苷(NA)经治患者序贯聚乙二醇干扰素α(PEG IFNα)治疗可大幅度提高其临床治愈率,其中优势患者HBsAg清除率可高达20%-80%。

后续NA序贯PEG IFNα提高临床治愈率的研究陆续发表,如浙江省人民医院的相关研究、香港研究、和S-Collate研究等。同时,NA联合PEG IFNα的探索研究发现了与序贯研究同样较高的临床治愈率,如S-C研究、Anchor研究、Icure研究等。近年来多项研究开始探索NA序贯或联合PEG IFNα的疗效差异,欲寻求最佳的临床治愈方式。

对特殊人群,如儿童、烟花巷ios官网非活动性HBsAg携带者等的临床治愈的探索研究发现了高于普通人群的临床治愈机会,还需要更多的研究去积累证据。

详情

(长图内容请横屏观看)

注:序贯或联合治疗是指核苷类药物序贯或联合聚乙二醇干扰素α治疗。

参考文献:(可上下滑动查看)

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